What is Nanoknife?來自Miami Valley Hospital 的 Shannon Kauffman, MD



　　soon and i think is a uh... procedure where we can insert probes into the body

　　using imaging guidance of c_t_ scan or ultrasound guidance

　　answer prose into

　　tours

　　and

　　once we get those probes positioned within the tumors we than they had been

　　to the man i visit use electricity

　　solely electricity tumor

　　and in that opens up a little tiny holes in the cells of the tumor cells

　　those cells than a week out their contents without money undergo

　　natural cell death

　　the advantage of the nam life over other

　　technology such as radiofrequency ablation which is is he to war cry

　　elation which uses freezing

　　is that upenn

　　use this to killed the tumor but it leaves the structure or

　　this running structures impact

　　so it leaves the proteins untouched annalise whatever structure in a mere

　　untouched reasonably

　　get rid of tissue next to blood vessels

　　you can

　　uh... be near file dot she can be next colin or small our believes those

　　structures untouched

　　whereas it will still going to kill the tumor

　　so it's very precise it has to be the needles have to be

　　one point five pt two centimeters part you can put of a rite of needles and

　　anywhere from two to seven needles in place or more than that and shape

　　if a tumors abnormally shaped

　　you can shape your

　　so killing zone

　　around to whatever the tumor shakers

　　we can be right next to the a border right next to be blood vessels

　　and those blood vessels will continue to

　　they kill themselves there's no injury to the blood vessel themselves because

　　that structure is left behind

　　how i hereby valley where

　　refers to bring us to tell

　　and we certainly have most experience in doing this uh... we've been doing this

　　for a number of years now and it's in a large number of patients

　　and that experience i think uh... as bio important in this because it is a very

　　meticulous process to be a little through

　　the uh...

　　arterial supply and then any that you see his different almost every patient

　　and to be able to recognize the strands and

　　certainly

　　procedure that requires a lot of experience

　　so then i feel very new and the patients are referred to us really consider using

　　a knife on our patients to

　　don't necessarily have another option

　　and if they have a tumor that's right next to a very large blood vessel

　　uh... something that we can't use radiofrequency ablation on weekends

　　probably shimon and not a surgical candid

　　and we can consider using nandonet because it leaves those blood vessels in

　　large bile ducts were bal intact

　　and um... work it's next to the year order or something along those lines

　　those are all structures that you can't

　　heat up or and or freeze because you'll destroy those tissues as well

　　eventually mannequins will kill cells believes that structure in place

　　so you can be right next to those structures you can believe across that

　　blood vessel

　　and that blood vessel continue flowing if you've got to murder comes right up

　　and wraps around a blood vessel even a blade on either side of that

　　you can use them in a night to collect tissue on either side of that the blood

　　vessel will be endangered

　　so those of the patients we use this in those patients that don't have another

　　option or isn't that right next door critical structure that we can't

　　find another technology

　　reviews it alright you things we've used and sarcomas

　　uh... we've used it on

　　endometrial cancer aids fusion on you can use it on any type of cancer

　　it will kill cells no matter where it's at

　　so just a matter of of

　　getting the protest if you can get into the creek location with the probes

　　so that as of now and i for why dressings one

　　these are patients who don't have another option

　　they have no other options for treatment is not surgically accessible or not a

　　searchable candidate

　　it's next to structures that can't be safely treated with reprieve principal

　　ational probably should

　　uh... so that's the basic there's the other manages that it's a minimally

　　invasive procedure

　　there are

　　small incisions that we make that we don't have to put state-run mandate

　　placed on apt word

　　who typically caper patients in overnight

　　uh... just for any pain control if they are having any pain we have not had

　　anybody that had any significant pain with this procedure

　　that's also the wash them to make sure that i have any complications that

　　coverage

　　uh... typically patients are sent home the next day

　　uh... procedures performed under general anesthesia

　　and so they're not

　　put them under

　　they wake up and it's all gone

　　no significant pain or anything like that with him

　　great minimally invasive

　　we can go back and do it again if need be or for another tumor pops up

　　somewhere else

　　uh... that's is accessible or an energetic and before you can certainly

　　go back and there's no

　　limitation a number of times you could do it

　　uh...

　　it's a very time intensive

　　procedure

　　it's a very uh...

　　has to be very precise to be a would do this we need to have high-quality

　　imaging to be able to do this in

　　we typically do this with the c_t_ scans not placer needles and to get the

　　needles in the crack location and then we have to use that david to make a

　　three-d_ image to be able to make your house at how far

　　the distances between approach and then we input that

　　information of the computer

　　and we can just mention a paraplegic p_o_

　　to be able to do that

　　now type is

　　here the reasons here at my god we uh... took place in town hasn't we were the

　　first center and the state of ohio to happen

　　there's no one else in town that has this

　　ability to get would do this and reach these tumors that are otherwise

　　inaccessible



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